This session will discuss the FDA-approved and non-FDA-approved medications available in the U.S. for the treatment of adults with ADHD. I will discuss the categories of medications- stimulants, non-stimulants, alpha2 agonists, off-label antidepressants, and alerting agents. While many patients respond to the first two medications tried, the clinical challenge is optimally medicating those patients who don't respond well to FDA-approved daily dosing recommendations. This session will highlight a clinical sequence of decision-making about dosing and medication combinations for persistent symptoms.