Low motivation is one of the most common presenting concerns in mental health care, yet it is frequently misunderstood across diagnostic categories. Clients who report difficulty initiating tasks, sustaining effort, or “getting started” are often assumed to be depressed or unmotivated, when the underlying drivers may reflect ADHD, anxiety, depression, or autistic processing differences. Because these conditions can share surface-level symptoms, clinicians must carefully assess the underlying mechanisms contributing to motivational difficulties. This session examines low motivation across ADHD, depression, anxiety, and autism. Participants will learn how motivational challenges present differently across conditions, including ADHD-related reward processing differences, depressive anhedonia, anxiety-driven avoidance, and autistic cognitive or sensory overload. The session will highlight similarities, diagnostic distinctions, and strategies for assessment, focusing on why accurate differentiation matters for treatment planning, medication decisions, and psychotherapy approaches. The presentation will integrate case studies, and participant interaction to identify the likely drivers of low motivation in brief clinical scenarios. The session concludes with a guided small-group discussion using structured prompts, allowing attendees to apply the framework to their own clinical practice and leave with practical tools for improving diagnostic clarity and treatment outcomes.