In this session, participants will learn to better identify and support female clients with Attention Deficit Hyperactivity Disorder (ADHD) presenting with symptoms of Rejection Sensitivity (RS). The session will begin with an overview of ADHD in girls and women, including the Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria of ADHD, recent scholarship, and clinical observations. Although more research is needed to understand the mechanism and prevalence of RS, in clinical practice identifying and understanding how females with ADHD may feel and act differently in interpersonal relationships can prove very powerful and meaningful. By providing a developmental overview of how ADHD and RS may present during childhood, adolescence, and adulthood, this session is intended to raise awareness for identifying and supporting female clients who are struggling with emotional dysregulation and interpersonal relationships through the lifespan. A case vignette will illustrate presentation of ADHD with RS and different interventions to consider when working with the young woman navigating demands of school, family, and friends, as well as later in treatment once in the workforce and dating. There will be concrete recommendations on making appropriate referrals and how to support female clients to thrive at home, school, and the workplace.